Evodiamine (evodia) and weight loss
What is it?
Evodiamine is an alkaloid plant extract that has been used in supplements with the intention of promoting weight loss. It is reported to have many characteristics of cayenne, including thermogenesis and analgesic (pain relief) use, without the same hot peppery effect. It’s allegedly beneficial to those that desire to lose weight and/or have extra endurance. Find out more details about this supplement in this comprehensive review of it below. On the end you’ll find our verdict.
Where does evodiamine come from?
Evodiamine is a major alkaloid found in the Evodia fruit family, commonly called Evodia rutaecarpa or Evodiae fructus. Evodia fruit is commonly used in China for its positive effects on digestive disturbances and as an analgesic.
What are the possible benefits of taking this bioactive alkaloid?
So what does evodiamine do and how does it work? Varying claims have arisen about the possible benefits of taking supplements containing this plant extract.
Evodiamine has been shown to have promise in increasing metabolism and reducing fat storage by raising core body temperature. There is also an indication that points to appetite suppression by way of increasing cholecystokinin (CCK), a hormone responsible for sending a signal to the brain to stop eating, and delayed gastric emptying.
Do any foods contain evodiamine?
No, it’s only available through the plant Evodiae Fructus and via supplement form.
What does the science & research say about it?
Despite a lack of human clinical trials using evodiamine, there are still promising results when it comes to fat loss. In a 2001 research article in Planta Medica, rats given evodiamine showed significant fat loss compared to a control group. An interesting finding of the study was that evodiamine could induce heat loss at the same time as a heat production increase. This indicates less fat storage and weight gain from food intake.
From this, the researchers concluded that there was a more efficient use of food energy when evodiamine was used. In the same study, there was evidence that evodiamine may effectively stimulate brown adipose tissue thermogenesis, which points to a heightened fat loss effect. So, similar to it’s capsaicin counterpart, evodiamine has effective metabolism boosting and fat loss properties, without the fiery kick.
There are no human studies using either evodia extracts or evodiamine, but the animal studies cited above do at least look promising.
What does the real world say for weight loss?
Supplements containing Evodia extract are claimed to produce a warm, “shivering” response, which is probably due to its receptor binding and vasodilating effects. But user feedback is inconsistent-meaning, not everyone seems to experience this reaction.
Evodia extracts are sold in blends with other compounds, so it’s difficult to evaluate what—if any—the fat loss effects are. Feedback on supplements containing them is mixed, and the results are inconsistent.
It may not work in humans, or it may be that an inadequate dose is provided.
At this time there is not enough scientific information to determine an appropriate range of doses for evodia.
What are the possible side effects of taking evodiamine?
There are no clinical studies on human participants available to date about the side effects associated with evodiamine supplementation. Consult your physician before taking evodiamine. It is necessary to carry out more research about this alkaloid to ensure that it is safe and effective for you.
Closing thoughts: Is this supplement worth the expense?
Evodiamine allegedly acts as a thermogenic and has the unique ability, as mentioned above, to increase your overall resting core temperature. Many believe that this is the reason more calories and fat are burned for energy when taking evoidaimine. However, it has been shown to work in research conducted using mice and other rodents, but no studies have yet been conducted on humans. Therefore we don’t recommend taking this product. It is important that the information is based on proven results in human test subjects in order to ensure the product is both safe and effective. We don’t even have a clue what the effective human dose is or if it’s even effective in humans at all, much less the needed safety data! Don’t waste your $$$ on this one.